I'm a Notre Dame fan, and both conferences are very weak this year. The ACC isn't that great, nor is the SEC.
Florida/Bama would probably dominate any ACC team. I think GT could give either a fit, and make it interesting for 3.5 quarters.
All the other conference match-ups are arguable, and anyone could live. Would produce some really exciting games, I think.
Pac-10 vs SEC.. could produce interesting match-ups as well.